| Thursday 25 October 2018 | 1 | x | 2 |
| 18:55 | Qarabag FK vs FC Vorskla Poltava | 0.70 | 2.70 | 4.25 | +72 |
| 18:55 | Sporting vs Arsenal | 2.25 | 2.35 | 1.25 | +73 |
| 18:55 | Anderlecht vs Fenerbahce | 1.40 | 2.40 | 1.95 | +73 |
| 18:55 | FC Copenhagen vs SK Slavia Prague | 1.45 | 2.25 | 1.95 | +73 |
| 18:55 | FC Zenit St Petersburg vs FC Girondins Bordeaux | 0.75 | 2.60 | 3.85 | +73 |
| 18:55 | AEK Larnaca FC vs Ludogorets 1945 Razgrad | 1.90 | 2.25 | 1.55 | +73 |
| 18:55 | FC Zurich vs Bayer Leverkusen | 3.30 | 2.75 | 0.80 | +73 |
| 18:55 | FC Spartak Trnava vs GNK Dinamo Zagreb | 3.60 | 2.60 | 0.80 | +73 |
| 18:55 | F91 Dudelange vs Olympiacos | 4.75 | 3.00 | 0.60 | +73 |
| 18:55 | RB Leipzig vs Celtic FC | 0.45 | 3.85 | 5.50 | +73 |
| 18:55 | AC Milan vs Real Betis Balompie | 0.95 | 2.65 | 2.90 | +73 |
| 18:55 | FC Salzburg vs Rosenborg BK | 0.22 | 5.50 | 10.75 | +72 |
| 21:00 | PAOK FC vs Vidi FC | 0.35 | 3.85 | 8.00 | +73 |
| 21:00 | Sarpsborg vs Malmo | 2.00 | 2.30 | 1.45 | +73 |
| 21:00 | Besiktas JK vs KRC Genk | 1.15 | 2.50 | 2.35 | +73 |
| 21:00 | Villarreal vs SK Rapid Vienna | 0.45 | 3.75 | 6.25 | +73 |
| 21:00 | Rangers FC vs FC Spartak Moscow | 1.35 | 2.45 | 2.05 | +73 |
| 21:00 | Eintracht Frankfurt vs Apollon Limassol FC | 0.50 | 3.50 | 5.00 | +73 |
| 21:00 | Olympique Marseille vs Lazio | 0.90 | 2.80 | 2.80 | +74 |
| 21:00 | Sevilla vs Akhisar Bld Spor | 0.14 | 7.50 | 16.25 | +72 |
| 21:00 | Stade Rennes vs FC Dynamo Kiev | 1.40 | 2.20 | 2.15 | +73 |
| 21:00 | Standard Liege vs FC Krasnodar | 1.55 | 2.45 | 1.70 | +73 |
| 21:00 | FK Jablonec vs FC Astana | 1.20 | 2.30 | 2.45 | +73 |
| 21:00 | Chelsea vs BATE Borisov | 0.12 | 7.50 | 20.00 | +72 |
