| Friday 28 September 2018 | 1 | x | 2 |
| 20:30 | KV Kortrijk vs AS Eupen | 0.95 | 2.45 | 2.40 | +76 |
| Saturday 29 September 2018 | 1 | x | 2 |
| 18:00 | KRC Genk vs SV Zulte Waregem | 0.40 | 3.65 | 5.25 | +75 |
| 20:00 | Royal Mouscron vs Waasland-Beveren | 1.05 | 2.30 | 2.25 | +75 |
| 20:00 | Royal Charleroi SC vs Sporting Lokeren | 0.55 | 2.85 | 4.25 | +75 |
| 20:30 | Club Brugge vs Cercle Brugge | 0.35 | 3.80 | 6.25 | +75 |
| Sunday 30 September 2018 | 1 | x | 2 |
| 14:30 | Anderlecht vs St. Truidense VV | 0.40 | 3.35 | 5.25 | +75 |
| 18:00 | KV Oostende vs Standard Liege | 2.85 | 2.55 | 0.80 | +76 |
| 20:00 | Royal Antwerp FC vs KAA Gent | 1.30 | 2.25 | 1.85 | +75 |
